Age-related macular degeneration is a major cause of blindness worldwide believed to affect more than 20% of ageing populations in many countries. Advanced age-related macular degeneration, including neovascular age-related macular degeneration (wet) and geographic atrophy (late dry), is associated with substantial, progressive visual impairment. Major risk factors include cigarette smoking, nutritional factors, cardiovascular diseases, and genetic markers, including genes regulating complement, lipid, angiogenic, and extracellular matrix pathways. Accurate diagnosis combines clinical examination and investigations, including retinal photography, angiography, and optical coherence tomography. Treatment for neovascular age-related macular degeneration incorporates intraocular injections of anti-VEGF agents, occasionally combined with other modalities. However, there has been no evidence of improvement of quality of vision. Currently, no proven therapies for atrophic disease are available. Ayurveda treatment at Sudarshanam has shown to slow the progression of the disease and improve the quality of the vision in most cases.